BASIC ASSUMPTION –
CAUSE of BPH
BPH is caused by low
bioavailable levels of testosterone, high levels of DHT and ESTROGEN
binding with the hormone receptor sites on the prostate gland. This
stimulates cell growth.
TREATMENT of BPH
By elevating the bioavailabity
of testosterone and reducing DHT and Estrogen or blocking their ability
to bind with the prostate, the prostate gland will normalize in size and
You can increase your
testosterone levels if they are low by supplementing with testosterone,
DHEA, pregnenelone or androsteine. You should monitor your levels of
testosterone to make sure that you don’t exceed the normal range. Many
men increase their testosterone levels only to see a corresponding
increase in estrogen, DHT and SHBG. This will cause more problems that
it solves. You must inhibit the conversion of testosterone into its
HORMONE BINDING HORMONE GLOBULIN)
Testosterone is the chief “male” hormone, produced in men by the Leydig
cells in the testes. As testosterone is
released into the bloodstream, much of it becomes bound to carrier
proteins called SBHG and albumin. The liver produces SBGH in order to
control levels of sex hormones which are biologically available.
SHBG also increases with
age. A study of men age 39 to 70 found that only 20 percent of men over
55 were considered to have low testosterone levels based on total
testosterone levels alone. Total testosterone levels include both bound
and free testosterone. When they looked at the biologically active
testosterone levels alone however, over 50% were deficient.
portion of testosterone becomes bound to albumin and until recently this
too was thought to be biologically inactive. New research shows that
while it may not be as active as free or unbound testosterone, it is
still useful and functional. Roughly 20 percent of testosterone
is bound to albumin.
Only a small fraction (1-5%) of a given amount of steroid hormone breaks
loose from the carrier protein in the bloodstream and is free to enter
target tissues. This free or unbound hormone can be measured with a
saliva test whereas the total levels are measured with a blood test.
nettle root extract has been shown to contain compounds that bind to
SHBG, reducing the binding of testosterone to SHBG, and the binding of
SHBG to prostate tissue
DHT - IS A METABOLITE OF
TESTOSTERONE THAT HAS BEEN ALTERED BY AN ENZYME CALLED 5-ALPHA REDUCTASE
By limiting 5-alpha reductase,
DHT levels are correspondingly reduced.
NINE ALPHA REDUCTASE
INHIBITORS ARE AS FOLLOWS:
is something every middle aged man should be supplementing with. It acts
as both a reductase inhibitor and an aromotase inhibitor as well. The
prostate gland has a great affinity for zinc and no other gland or organ
in the body has as much zinc as the prostate. The prostate concentration
of zinc is ten times lower in cancer of the prostate than in normal
prostate or BHP. Zinc is also used by the immune system to fight
infection and there is a relationship between low levels of zinc and low
levels of testosterone. Supplement with 50 to 100 mg’s of zinc per day
and always take vitamin B6 with zinc.
is a proven reductase inhibitor and has been shown to have other
beneficial effects on the prevention and inhibition of PC
is another reductase inhibitor that has down regulating effects on
testosterone. In addition, lycopene decreased the expression of two
prostatic cytokines, IGF-I and IL-6, both regarded as risk factors for
is an herb that is legendary for prostate issues and has been proven to
be more effective that most drugs at reducing 5- alpha reductase. The
liposterolic extract of Saw Palmetto has three major activities that
improve BPH symptomology, they include: Inhibition of 5-?-reductase;
Inhibiting the binding of DHT to prostatic cells; and Inhibiting both
Lipoxygenase and Cyclooxygenase (arachidonic acid cascades) Saw
Palmetto, by competing with both the enzyme and receptor that stimulates
growth factor secretion, inhibits hyperplasia.
is the active ingredient in saw palmeto
is a hormone which serves as a reductase inhibitor as well as an
antitagonist to estrogen. Research Studies have shown that when prostate
cells are exposed to estrogen, the cells proliferate and become
cancerous. When progesterone or testosterone was added, cancer cell
dies. During the aging process, progesterone levels fall, especially
after age 60. Progesterone is the chief inhibitor of 5-alpha reductase.
When the level of progesterone falls, the amount of conversion from
testosterone to DHT increases. Make sure to supplement with natural
progesterone cream. Avoid the synthetic pharmaceuticals at all cost.
Linolenic Acid (GLA),
Alpha Linolenic Acid
and Linoleic Acid are essential fatty acids found in plant oils.
GLA, ALA, and Linoleic Acid have been individually shown to inhibit
5-Alpha Reductase. In fact these are powerful inhibitors of 5-Alpha
can also be caused by an enzyme called PROLACTIN. Prolactin is
inhibited by the hormone Melatonin. Melatonin is produced as we
sleep in total darkness, any light which falls on any part of the
body will halt the secretion of melatonin and supplementing becomes
necessary. Vitamin B-6 also decreases prolactin and should be used
Zinc also reduces prolactin binding to prostate receptors
ESTROGEN IS A METABOLITE OF TESTOSTERONE WHICH HAS BEEN ALTERED BY THE
are “hot spots” of aromatase activity. Aromatase converts testosterone
and its derivative androstenedione to estrogen. Fat tends to replace
muscle with aging in men, thereby increasing aromatase levels. By
gaining muscle mass and sheding body fat, you naturally limit aromatase.
nutrients you can consume which inhibit aromatase as well. Known
Aromatase inhibitors are:
is linked to aromatase, if vitamin C levels are low then aromatase
levels rise and high levels of this vitamin will sometime stimulate the
pituitary gland to activate the testosterone production to begin.
found in olive oil and flax seed and flax seed oil
skins and seeds
such as quercetin; kaempferol; naringenin and apigenin.
One research reported quercetin was 1.5 times more effective than drugs
used to inhibit aromatase and that apigenin was 8.5 times more
effective.. There no supplemental sources of apigenin, but you get them
from celery, peppermint, parsley and gingo biloba. Quercetin is found in
many fruits and vegetables such as applaes and onions, you can get it in
supplement form as well.
is another powerful aromatase inhibitor which is extracted from bee
propolis as well as plants.
Luteolin has been shown in vitro to be a strong inhibitor of aromatase.
Apigenin, which differs from luteolin only be one oxygen atom, has also
been shown to be a strong aromatase inhibitor. In vitro (test tube)
activity often does not translate into in vivo (live animal) activity,
especially in the case of flavonoids such as chrysin, due to “relatively
poor absorption and/or bioavailability. However, luteolin has been shown
in human and animal studies to have excellent absorption and
bioavailability, and to exert powerful protective effects, even at low
CAN BE PROHIBITED FROM BINDING WITH THE PROSTATE
Progesterone has strong affinity for the prostate and will compete for
available binding sites, thus preventing estrogen from binding with and
stimulating both benign and cancerous growth.
soy foods contain high amounts of plant or phyto estrogens. These
estrogens are very weak and have almost no harmful effects. However,
they compete with the available binding sites and prohibit the more
potent and harmful estrogen. This causes the plasma estrogen levels to
increase and thus stimulates the liver to metabolize the estrogen.
CAN BE METABOLIZED
Methods of metabolism
which is derived from the cruciferous vegetables, niacin, vitamin C
and resveratrol which is found in grape skins and seeds are vital in
aiding the livers efforts to metabolize estrogen. A healthy liver
will do two things, it will metabolize and it will bind estrogen
with bile acids and send it to the colon for excretion. A funny
thing happens with most men at this point. If you don’t have the
right bacteria in the digestive tract, the bile is cleaved from the
estrogen and the estrogen gets reabsorbed into the blood stream.
Castor oil helps the liver to function so that estrogen is metabolized.
Use only cold pressed castor oil and wool flannel cloth (white), you can
rub some oil directly over the liver and then soak the piece of flannel
with oil and place it over the liver. Place some plastic wrap over the
cloth and apply a heating pad for one hour. Do this each day for two
weeks and then every other day. This will also reduce cholesterol levels
and enable the liver to remove other toxins from the body.
You can reuse the cloth several times by placing it in a freezer bag. It
will eventually turn a dark color and then you can discard it.
Heavy drinking in men has long been recognized as causing high ESTROGEN
LEVELS with which such related symptoms as spider veins, reddish
coloration of the palms, gynecomastia (enlarged breast), and even
testicular atrophy. Increased sexual dysfunction is also common.
Shakespeare noted that alcohol “increases the desire but decreases the
performance,” and there is every reason to believe that alcohol-induced
estrogen rises are a significant part of the effect. This was taken from
“THE TESTOSTERONE SYNDROME”. Alcohol blocks the livers ability to
metabolize estrogen by inhibiting the P450 system.
ACTION FOR ESTROGEN.
Progesterone cream, 12 mg of natural progesterone per day.
and SOY ISOFLAVONES
which are obtained by eating soy, foods with soy such as soy milk
and tofu as well as taking soy isoflavone supplements will compete
with the estrogen receptor sites in the body. This is important
because phytoestrogens are 1/500th as potent as the most dangerous
form of estrogen, estradiol. The body senses the estrogen level to
be high and stimulates the P450 system in the liver to metabolize
the estrogen. This added to the nutrients listed above as
stimulators of estrogen metabolism will keep estrogen levels where
they should be.
Many chemicals found in our environment such as herbicides and household
chemicals as well as heavy metals act as estrogen and bind with the
prostate. To remove these xenoestrogens, there are substances which will
bind to these xenoestrogens and escort them to the colon for removal.
are the best chelators.
SUGGESTIONS FOR BPH
By normalizing hormone levels
the prostate issues that confront the majority of men as they age should
be eliminated. By utilizing the information we have about hormones, this
is a practical task for every man to undertake regardless of his age.
Click here to learn more about our BPH Protocol